The HARPER Lab

Department of Cell Biology

Publication - 750

Ordureau A, Sarraf SA, Duda DM, Heo J-M, Jedrykowski MP, Sviderskiy V, Olszewski JL, Koerber JT, Xie T, Beausoleil SA, Wells JA, Gygi SP, Schulman BA, and Harper JW (2014) Quantitative proteomics reveal a feed-forward mechanism for mitochondrial PARKIN translocation and UB chain synthesis. Molecular Cell, 56: 360–375.

Publication - 749

Ikeuchi Y, Dadakhujaev S, Chandhoke AS, Huynh MA, Oldenborg A, Ikeuchi M, Deng L, Bennett EJ, Harper JW, Bonni A, Bonni S. (2014) TIF1γ Protein Regulates Epithelial-Mesenchymal Transition by Operating as a Small Ubiquitin-like Modifier (SUMO) E3 Ligase for the Transcriptional Regulator SnoN1. J Biol Chem. 289:25067-25078.

Publication - 746

Scott DC, Sviderskiy VO, Monda JK, Lydeard JR, Cho SE, Harper JW, Schulman BA. (2014) Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8. Cell 157:1671-1684.

Publication - 745

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH. (2014) Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512:49-53.

Publication - 742

Mancias JD, Wang X, Gygi SP, Harper JW*, and Kimmelman AC*. (2014) Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature, 509:105-109. (image: Eric D. Smith and Joseph D. Mancias)

Publication - 737

Guarani, V., Paulo, J., Zhai, B., Huttlin, E.L., Gygi, S.P., and Harper, J.W. (2014) TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial Complex I assembly factor through association with the MCIA complex. Molecular and Cellular Biology, 34:847-861.

Publication - 734

Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 203:457-470.

Publication - 733

Mejia LA, Litterman N, Ikeuchi Y, de la Torre-Ubieta L, Bennett EJ, Zhang C, Harper JW, Bonni A. (2013) A Novel Hap1-Tsc1 Interaction Regulates Neuronal mTORC1 Signaling and Morphogenesis in the Brain. J Neurosci. 33:18015-21.

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