Department of Cell Biology


Sep 2013

Our paper on a new method for proteomic identification of substrates for SCF and CRL ubiquitin ligases just appeared in the on-line edition of Molecular Cell. Congratulations to Marcus Tan for pulling the paper together and for defending his dissertation.

Meng-Kwang Marcus Tan, Hui-Jun Lim, Eric J. Bennett, Yang Shi, J. Wade Harper (2013) Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF-FLXL17 in NRF2 Activation via BACH Repressor turnover.  Molecular Cell52:9-24

Jul 2013

Our paper with Eric Baehrecke's lab at UMASS on ATG7-ATG3 independent autophagy appeared!

Chang T-K, Shravage BV, Hayes SD, Powers CM, Simin RT, Harper JW, and Baehrecke EH. (2013) Uba1 functions in Atg7- and Atg3-independent autophagy. Nature Cell Biology, 15:1067-78.

Jul 2013

Our collaboration with Azad Bonni's lab on the PHF6 protein and intellectual disability appeared in Neuron!

Zhang C, Mejia LA, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, Rudnicki M, Harper JW, and Bonni A. (2013) The X-linked Intellectual Disability Protein PHF6 Associates with the PAF1 Complex and Regulates Neuronal Migration in the Mammalian Brain. Neuron 78:986-993. 

May 2013

Our paper on Parkin substrates appeared and Shireen graduated!!

Sarraf S, Raman M, Guarani-Pereria V, Sowa ME, Huttlin EL, Gygi SP, and Harper JW. (2013) Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Nature 496:372-376.


May 2013

Shireen successfully defended her thesis and obtained her PhD soon after publishing her paper on the PARKIN-modified proteome (in Nature). Congratulations to Shireen!

Nov 2012

Alban Ordureau joined the lab as a post-doc. He recently completed his PhD with Phil Cohen in Dundee. Welcome Alban!

Jul 2012

Christian Munch was awarded a long-term EMBO Fellowship. Congratulations to Christian!

May 2012

Popovic D, Akutsu M, Noval I, Harper JW, Behrends C, Dikic I. (2012) Rab GAPs in Autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers. Mol Cell Biol, in press.

Apr 2012

Christian Munch joined the lab in April, after recently completing his PhD in Anne Bertolotti’s lab at the LMB in Cambridge. There he worked on prions and molecular chaperones. We are excited to have Christian join the lab!

Feb 2012

Post-doctoral Fellow Anne White received an NRSA Fellowship from the NIH. Congratulations to Anne!

Feb 2012

Chris Behrend’s first corresponding author paper was accepted in a great collaboration with Ivan Dikic......

Jan 2012

Laura in the lab just learned that she is the recipient of a 2012 Damon Runyun Post-doctoral Fellowship. Congratulations to Laura!