News
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Happy to announce that Miguel Gonzalez-Lozano (from the Smit lab in Vrije Universiteit Amsterdam) is joining the lab this week!! We are excited to have you and look forward to lots of fun and cool experiments. |
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Excited that our collaboration with the Mugit lab on Parkin targets in primary neurons is now out! Really fun to work with Miratul and Odetta! Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK. Science Advances. 2021 Nov 12;7(46):eabj0722. doi: 10.1126/sciadv.abj0722. Epub 2021 Nov 12. |
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Happy to announce the publication of Alban's last major paper from the lab - tour-de-force proteomic analysis of neurogenesis and examination of the role of autophagy. With major contributions by Felix, Heeseon, Joao and Jill. Ordureau A, Kraus F, Zhang J, An H, Park S, Ahfeldt T, Paulo JA, Harper JW. Molecular Cell. 2021 Oct 15:S1097-2765(21)00800-5. doi: 10.1016/j.molcel.2021.10.001. Online ahead of print. |
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Happy to announce that Vinay, Melissa, Sharan's and Joao's paper on the role of TAX1BP1 and TBK1 in lysophagic flux appeared in Elife. Check it out: https://elifesciences.org/articles/72328.
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Happy to announce that Bobby Hollingsworth (recently graduated from HMS BCMP and Hao Wu's lab) and Chan Lee (recently graduated from Mike Overholtzer's lab at MSKCC) are joining the lab this week!! We are excited to have you and look forward to lots of fun and cool experiments. |
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Our collaborative paper with Danielle Garshott and Eric Bennett @UCSD describing iRQC - a surveillance pathway for 40S ribosome quality control during mRNA translation initiation is now out in Cell Reports. Interesting use of Ribo-Halo and Ribo-Keima developed previously in the lab by Heeseon An to decode mechanisms of 40S degradation occuring likely as a result of ribosome collisions during translation initiation. Check it out at: https://www.cell.com/cell-reports/pdf/S2211-1247(21)01085-8.pdf |
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We are sorry to see Hankum leave the lab to start his Assistant Professor position in South Korea but we are excited about his new opportunities! Good luck with everything Hankum - it was great to have you in the lab these last 3 years! |
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Just released on BioRxiv - our latest work from Team Lysophagy (Vinay, Sharan, and Melissa) describing a proteomic analysis of lysophagy using proximity biotinylation and lyso-IP. We identified TAX1BP1 as a critical cargo adaptor involved in lysophagic flux, as measured using a new lyso-Keima assay. {https://www.biorxiv.org/content/10.1101/2021.07.19.452535v1} |
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Introducing Frances Hundley, a new postdoc in the lab who comes to us from the Toczyski lab at UCSF, and Julia Paoli, a research assistant, who comes to us from the University of Illinois. Welcome to you both!! |
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Many CONGRATULATIONS! to Walter, who has been named a 2020 STAT Wunderkinds! Great news...https://www.statnews.com/wunderkinds/ |
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Check out out paper with Rachel Green identifying EDF1 as a key regulator of ribosome collisions - great application fo TMT proteomics to discovery new proteins in polysomes (EDF1). https://elifesciences.org/articles/58828 |
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Congratulations to our neighbors in the Shao lab for the great collaboration with Alban in the lab on the identiifcation of ATP13A1 as a transmembrane dislocase that removes mislocalized tail-anchored proteins from the ER. Such mis-localized proteins include those that normally are localized to mitochondria. Thanks for the great collaboration! https://pubmed.ncbi.nlm.nih.gov/32973005/ |
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Very happy to announce that Kelsey Hickey and Felix Kraus have joined the lab. Kelsey was a graduate student in Jonathan Weissman's lab at UCSF and worked on ribosomal quality control (RQC), including a recent paper in Mol Cell. Felix was a graduate student in Mike Ryan's lab in Melbourne and worked on Dynamin and mitochondrial fission/fusion dynamics. Welsome to both!! |
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Congratulations to Heeseon and Alban on the publication of their new paper in Nature! An H, Ordureau A, Körner M, Paulo JA, Harper JW. Systematic quantitative analysis of ribosome inventory during nutrient stress. Nature. 2020;583(7815):303-309. doi:10.1038/s41586-020-2446-y |
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Excited to have Ellen Goodall (from Andy Martin's lab at Berkeley) join the lab as a post-doc and Alex Panov join the lab as a graduate student from the BBS program. |
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Excited to have Melissa Hoyer join the lab! Recent alum from Gia Voeltz's lab (UC Boulder). |
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Congratulations to Heeseon and Alban on the publication of their new paper in Molecular Cell identifying a new ER-phagy receptor TEX264. An H, Ordureau A, Paulo JA, Shoemaker CJ, Denic V, Harper JW. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress. Mol Cell. 2019 Apr 11. pii: S1097-2765(19)30258-8. doi: 10.1016/j.molcel.2019.03.034. [Epub ahead of print] |
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Congratulations to Jin-mi, whose paper on TBK1 and RAB7A appeared recently in Science Advances. In this work, we identify S72 in RAB7A as a target of TBK1 in response to mitochondrial depolarization and activation of the PARKIN pathway for mitophagy. Heo et al., RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway. Science Advances (http://advances.sciencemag.org/content/4/11/eaav0443). |
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Alban's paper describing digital snapshots of PARKIN activity on mitochondria using Parallel Reaction Monitoring is out in Molecular Cell: Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics. Mol Cell. (2018) 70:211-227. |
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Our new review on the Parkin-Pink1 pathway is out in a special issue of Nature Reviews - Molecular Cell Biology focused on mitochondrial biology. Check it out! http://www.nature.com.ezp-prod1.hul.harvard.edu/nrm/journal/v19/n2/index... |