News - 10/20/2016

Congratulations to David Rhee in the Harper lab and Danny Scott in the Schulman lab for the recent publication of a paper in Cell describing ARIH1 as an RBR class ubiquitin ligase that works in unison with cullin-RING E3s to control substrate ubiquitylation. This exciting collaboration revealed a new ubiquitin transfer mechanism at play for a subset of CRLs involving CUL1, CUL2, and CUL3 based CRLs.