BioPlex - Human Interactome

The human interactome is composed on thousands of interactions and protein communities. Using a robust interaction proteomics platform, we - together with the Gygi lab - have performed interaction proteomics on more than 10,000 human genes in 2 cell lines, thereby creating BioPlex 3.0 - the largest such network in existence. We are currently expanding this system to additional cell lines to understand how cellular diversity affects the organization of the proteome.